Anion transmembrane transport promoted by new synthetic molecules

    Ion transport across the phospholipid cell membranes is crucial to several biological processes. A combination of protein ion channels embedded in the membrane controls the ion concentrations in the cytosol and outside the cell. Dysfunctions in these channels are currently linked with the occurrence of certain pathologies, such as cystic fibrosis, caused by a defective transmembranar transport of chloride anions. Therefore, our aim is the development of synthetic transporters with potential to be applied as possible replacement therapeutics for malfunctioning channels. This work also comprehends anion binding, vesicle efflux, and cytotoxicity studies.

    Determination of the receptor binding constants by spectroscopic methods